When Should the GI Effects Microbial Ecology Profile Be Considered?
Patients with a clinical history suggestive of a gastrointestinal infection or dysbiosis can be evaluated with the GI Effects Microbial Ecology Profile. Symptoms such as gas, bloating, abdominal pain, diarrhea, and constipation may be a result of a microbial imbalance or infection. This profile can also be used to monitor treatment efficacy to eradicate an organism or to monitor changes to the microbiota.
Gut microbes are codependent with one another and with their human host, and the health of one affects the other. A sizeable volume of research associates a dysbiotic, or imbalanced gut microbiome with multiple disease states both within and outside of the GI tract.1,2 The microbiome's diverse metabolic activities ultimately impact the human host, and the human hosts activities ultimately affect the microbiome's health.
The GI Effects Microbial Ecology Profile is part of the larger GI Effects Comprehensive Stool Profile, which also provides information about digestion, inflammation, and bacterial metabolism markers. A larger faecal biomarker panel such as the GI Effects Comprehensive Stool Profile offers the advantage of assessing multiple functional areas that may be contributing to symptoms. For example, diarrhea could stem from multiple causes including pancreatic exocrine insufficiency, inflammation, food allergies, or the presence of a pathogenic or potentially pathogenic organism.
What is the GI Effects Microbial Ecology Profile?
The GI Effects Microbial Ecology Profile is the most comprehensive stool test that assesses the diverse gut microbiome. Results provide immediate, actionable clinical information for the management of detectable parasites, bacteria, and yeast, as well as providing valuable assessment of gut microbiota via 24 Commensal Bacteria targets.
The GI Effects Microbial Ecology Profile biomarkers include:
- Commensal Bacteria demonstrate the gut microbiomes composition and relative abundance.
- More than 95% of commensal gut organisms are anaerobic and are difficult to recover by traditional (aerobic) culture techniques. Polymerase Chain Reaction (PCR) methodology identifies bacterial populations and is considered the standard for anaerobic bacteria assessment.
- GI Effects assesses a set of 24 genera/species that map to 7 major phyla.
- Bacterial and mycology cultures demonstrate the presence of specific beneficial and pathological organisms.
- Bacteria and mycology sensitivities are provided for pathogenic or potentially pathogenic cultured organisms. The report includes effective prescriptive and natural agents.
- GI Effects provides microscopic faecal specimen examination for ova and parasites (O&P), the gold standard of diagnosis for many parasites.
- Enzyme immunoassay (EIA), widely recognised for its diagnostic utility in the detection of pathogenic antigens, is used for the identification of Cryptosporidium, Entamoeba histolytica, and Giardia lamblia.
- Selection of a one-day or three-day sample collection is based on clinician's clinical index of suspicion for parasitic infection. If there is no/low suspicion, a one-day sample will likely be adequate. For high suspicion, a three-day sample collection is optimal.
- Additional Biomarkers Available:
- Clostridium difficile
- Escherichia coli
- Helicobacter pylori
- Macro Exam for Worms
- KOH Preparation for Yeast
- Zonulin Family Peptide
- Faecal Lactoferrin
What Advantage Does the Microbial Ecology Profile Offer Compared to Other Diagnostics?
GI Effects Microbial Ecology Profile represents the best technical platform available to assess the gut microbiome, combining an anaerobic bacteria PCR molecular assay, Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) technology for cultivable species identification, and gold standard parasite detection O&P (ova & parasites).
The test report is organised so that the clinician can move through results in a logical order that enhances clinical utility, starting with the innovative Interpretation-At-A-Glance pages to synthesise the information.
What Can Clinicians and Patients Expect from GI Effects Microbial Ecology Profile Stool Testing?
The GI Effects Microbial Ecology Profile results provide insight into the root cause(s) of gut symptoms originating from a disturbed gut microbiome. Symptoms often improve as identified imbalances become normalised through targeted antimicrobial, dietary, lifestyle, and supplementation therapeutics.
The GI Effects Interpretive Guide is a convenient tool to support the therapeutic decision-making process for patients with complex gut-related conditions.
- Marchesi J, et. al. The gut microbiota and host health: a new clinical frontier. Gut. 2016 Feb;65(2):330-9.
- Clemente J, et. al. The impact of the gut microbiota on human health: an integrative review. Cell. 2012 Mar;148(6):1258-70.