ION Profile®

A Nutritional Analysis for Personalized Supplementation

Proceed to Clinical Overview

Why use the ION Profile?

The ION Profile is a nutritional analysis that measures over 125 key nutrient biomarkers and ratios that can help identify nutritional shortfalls that may be a root cause of complex chronic conditions. The ION Profile evaluates organic acids, fat-soluble vitamins, Coenzyme Q10, homocysteine, oxidative stress markers, nutrient and toxic elements, fatty acids, and amino acids.

Nutritional analysis using the ION Profile allows for personalized treatment plans to improve nutritional status, which can enhance other treatments and increase the resolution of complex chronic conditions.

Effective for Patients Experiencing:

Over time, functional nutritional inadequacies can contribute to a variety of chronic health conditions. Clinical indications for testing include:

  • Mood Disorders
    • Depression
    • Anxiety

  • Fatigue
  • Digestive Complaints
  • Chronic Pain/Inflammatory Conditions
    • Musculoskeletal
    • Migraine

  • Cardiovascular Risk
  • Weight Issues/Dietary Guidance
  • General Health and Sports Fitness Optimization

About the ION Profile

Using both blood and urine, the ION Profile nutritional analysis offers insight into imbalances that may precede abnormal findings on standard laboratory evaluations.

The complete ION Profile includes:

  • 20 Amino Acids
  • Nutrient and Toxic Elements
  • CoEnzyme Q10 plus Vitamins
  • DNA/Oxidative Stress Markers
  • Vitamin D
  • Fatty Acids
  • Organic Acids

The innovative ION profile report is designed for easy interpretation and enhanced utility:

  • Colorimetric quintile results reporting – allows quick identification of potential areas of concern
  • Analyte Pattern Analysis – organizes results into related functional categories
  • Supplement Recommendation Summary – personalized recommendations based on test results

The ION Profile is ideal for establishing a baseline assessment ahead of clinical intervention with nutraceuticals as well as subsequent monitoring as needed.

Clinical Overview

What are the ION Profiles (ION or ION with 40 Amino Acids)?

The ION (Individual Optimal Nutrition) is a nutritional analysis that offers a complete evaluation of nutritional biomarkers that impact overall mental and physical well-being. The original ION measures 20 amino acids, while the ION with 40 Amino Acids provides an expanded menu of amino acids when a more extensive look at amino acid status is desired. The complete ION profiles include:

  • Amino Acids (a choice of 20 or 40)
    • Essential Amino Acids
    • Amino Acid Functional Categories

  • Nutrient & Toxic Elements
    • Nutrient Elements
    • Toxic Elements

  • Coenzyme Q10 Plus Vitamins Profile
  • DNA/Oxidative Stress Markers
  • Vitamin D Profile
  • Fatty Acids Profile
  • Organix Comprehensive
    • Nutrient Markers
    • Cell Regulation Markers
    • Toxicants and Detoxification
    • Compounds of Bacterial or Yeast/Fungal Origin

The innovative ION report is designed for facilitated interpretation and enhanced clinical utility:

  • Colorimetric quintile results reporting – allows clinicians to quickly see where patient results fall in relation to the tested population, while color coding provides indications for potential areas of concern
  • Analyte Pattern Analysis – organizes analyte results into categories associated with clinical/metabolic conditions; patterns of abnormalities can reinforce degree of significance indicated by a single measurement
  • Supplement Recommendation Summary – personalized recommendations based on test results that may help to normalize nutrient-dependent metabolic functions

When Should an ION Profile be Considered?

The ION Profiles are designed to assist in the management of nutritional insufficiencies or imbalances. An ION Profile is ideal for establishing a baseline assessment ahead of clinical intervention with nutraceuticals as well as subsequent monitoring as needed.

The ION Profiles provide insight into the identification of specific imbalances of vitamins, nutrients, and essential co-factors, which can contribute to common chronic diseases.

Common clinical indications for nutritional analysis include:

  • Mood Disorders
    • Depression
    • Anxiety

  • Fatigue
  • Digestive Complaints
  • Chronic Pain/Inflammatory Conditions
    • Musculoskeletal
    • Migraine

  • Cardiovascular Risk
  • Weight Issues/Dietary Guidance
  • General Health and Sports Fitness Optimization

The ION Profile with 40 Amino Acids can be selected when a more detailed look at amino acid metabolism is desired; otherwise, the two profiles offer the same complete menu of biomarkers.

What Advantage Does an ION Profile Offer Compared to Other Diagnostics?

The conventional clinical approach to nutrition-related symptoms does not routinely include utilization of broad-based nutritional analysis. When testing is performed, select vitamins are typically assessed to determine if the level is sufficient to meet nutrient requirements based on healthy individuals. However, an inclusive nutritional analysis like the ION Profile provides several advantages for patients with nutrient-related symptoms.

  • Identification of imbalances that may precede abnormal findings on standard laboratory panels
  • Indication of the functional need for specific nutrients, diet modification, antioxidant protection, detoxification, and other therapies
  • Personalized nutrient recommendations based on biochemical individuality

What Can Clinicians and Patients Expect from ION Testing?

Imbalanced or insufficient nutrients affect a wide range of body functions, producing symptoms that negatively affect the quality of life and may play a causative role in chronic conditions. A structured broad-based nutritional analysisÑsuch as an ION ProfileÑto evaluate underlying nutrient imbalances provides clinical utility by supporting insight into the development of personalized treatments. An improved nutritional status can often enhance other therapies and help speed the resolution of complex chronic conditions.

Test Type: Blood Test

Analyte List
11-Eicosenoic Acid
2-Methylhippurate
25-Hydroxyvitamin D, Total
25-Hydroxyvitamin D2
25-Hydroxyvitamin D3
3,4 Dihydroxyphenylpropionate
5-hydroxyindoleacetate
8-Hydroxy-2'-deoxyguanosine*
AA/EPA
Adipate
Alpha-Hydroxybutyrate
Alpha-Keto-Beta-Methylvalerate
Alpha-Ketoglutarate
Alpha-Ketoisocaproate
Alpha-Ketoisovalerate
Alpha-Linolenic Acid (ALA)
Aluminum
Arachidic Acid
Arachidonic Acid
Arginine
Arsenic
Asparagine
Aspartic Acid
Behenic Acid
Benzoate
Beta-Carotene
Beta-Hydroxybutyrate
Beta-Hydroxyisovalerate
Cadmium
Calcium
Capric Acid
Citrate
Citrulline
Coenzyme Q10
Copper
Creatinine
D-Arabinitol*
D-Lactate*
Dihomogamma Linolenic Acid (DGLA)
Docasadienoic Acid
Docosahexaenoic Acid (DHA)
Docosapentaenoic Acid
Docosatetraenoic Acid
EPA/DGLA
Eicosadienoic Acid
Eicosapentaenoic Acid (EPA)
Ethylmalonate
Formiminoglutamate
Fumarate
Gamma Linolenic Acid (GLA)
Gamma Tocopherol*
Glucarate
Glutamic acid
Glutamic acid/Glutamine
Glutamine
Glycine
Heneicosanoic Acid
Heptadecanoic Acid
Hexacosanoic Acid
Hippurate
Histidine
Homocysteine
Homvanillate
Hydroxymethylglutarate
Indican
Isocitrate
Isoleucine
Kynurenate
L-Lactate*
LA/DGLA
Lauric Acid
Lead*
Leucine
Lignoceric Acid
Linoleic Acid
Lipid peroxides
Lysine
Magnesium
Malate
Mead Acid
Mercury
Methionine
Methylmalonate
Myristic Acid
Myristoleic Acid
Nervonic Acid
Nonadecanoic Acid
Oleic Acid
Ornithine
Orotate
Palmitelaidic Acid
Palmitic Acid
Palmitoleic Acid
Pentadecanoic Acid
Phenylacetate
Phenylalanine
Phenylalanine/Tyrosine
Phenylpropionate
Picolinate*
Potassium
Pyroglutamate
Pyruvate
Quinolinate
Selenium
Serine
Stearic Acid
Stearic/Oleic
Suberate
Succinate
Sulfate
Taurine
Threonine
Total C:18 Trans
Tricarballylate
Tricosanoic Acid
Tryptophan
Tryptophan/LNAA (Large Neutral Amino Acids)
Tyrosine
Vaccenic Acid
Valine
Vanilmandelate
Vitamin A
Xanthurenate
Zinc
cis-Aconitate
d-Alpha Tocopherol
p-Hydroxybenzoate
p-Hydroxyphenylacetate
p-Hydroxyphenyllactate
CPT Codes  
Specimen Requirements
Serum, ~9 ml (3 tubes, ~3 ml each), frozen; Plasma, 2.5 - 3 ml, frozen; Whole Blood, room temperature; Overnight Urine, 12 ml, frozen